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NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR


NMN is synthesized from nicotinamide, a form of water-soluble vitamin B3, and 50-phosphoribosyl-1-pyrophosphate (PRPP), by NAMPT, the rate-limiting NAD+ biosynthetic enzyme in mam- mals (Figure 1A) (Imai and Yoshino, 2013; Revollo et al., 2004; Wang et al., 2006). NMN is also synthesized from NR via an NRK-mediated phosphorylation reaction, which is discussed further in the…

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